Ọrịa strok, ọnọdụ na-agbawa obi nke a na-eji na mberede mbelata ọbara na-enye anụ ahụ ụbụrụ n'ihi hemorrhagic or ischemic pathology, bụ ihe nke abụọ na-ebute ọnwụ n'ụwa nile na nke atọ na-akpata nkwarụ. Ụdị isi abụọ nke ọrịa strok bụ ọrịa strok ischemic (na-aza 68%) na ọrịa strok hemorrhagic (32%). N'agbanyeghị pathophysiology ha dị iche na ọkwa mbụ, ha abụọ na-eduga na mbelata nke ọbara na ischemia cerebral na-esote n'oge usoro subacute na nke na-adịghị ala ala.
Ischemic ọrịa strok
A na-amata ọrịa strok nke Ischemic (AIS) site na nchichi nke arịa ọbara na mberede, na-ebute mbibi ischemic na mpaghara ahụ emetụtara. N'ime nnukwu oge, gburugburu ebe hypoxic a bụ isi na-ebute mkpọda nke excitotoxicity, nrụgide oxidative, na ịgbalite microglia, na-eduga na ọnwụ akwara ozi zuru oke. N'oge subacute usoro, ntọhapụ nke cytokines, chemokines, na matrix metalloproteinases (MMPs) nwere ike itinye aka na neuroinflammation. N'ụzọ doro anya, ọkwa dị elu nke MMPs na-abawanye ikike nke mgbochi ụbụrụ ọbara (BBB), na-enye ohere ịkwaga leukocyte n'ime mpaghara a na-adịghị ahụ anya, na-eme ka ọrụ mkpali dịkwuo njọ.
Ọgwụgwọ ugbu a maka ọrịa strok ischemic
Ọgwụgwọ mbụ dị irè maka AIS gụnyere thrombolysis na thrombectomy. Thrombolysis intravenous nwere ike ịbara ndị ọrịa uru n'ime awa 4.5, ebe ọgwụgwọ n'oge na-atụgharị na uru ka ukwuu. E jiri ya tụnyere thrombolysis, thrombectomy n'ibu nwere windo ọgwụgwọ sara mbara. Tụkwasị na nke ahụ, ndị na-abụghị ọgwụ ọgwụ, ọgwụgwọ ndị na-adịghị emerụ ahụ dị kaọgwụgwọ oxygen, acupuncture, na mkpali ọkụ eletrik na-enweta traction dị ka ọgwụgwọ mgbakwunye na ụzọ ndị a na-emekarị.
Ihe ndị bụ isi nke Hyperbaric Oxygen Therapy (HBOT)
N'ihe nrụgide dị n'oké osimiri (1 ATA = 101.3 kPa), ikuku anyị na-eku ume nwere ihe dịka 21% oxygen. N'okpuru ọnọdụ physiological, oke oxygen gbazere na plasma dị ntakịrị, naanị ihe dịka 0.29 ml (0.3%) kwa 100 ml nke ọbara. N'okpuru ọnọdụ hyperbaric, iku ume 100% oxygen na-abawanye ọkwa oxygen gbazere na plasma nke ukwuu-ruo 3.26% na 1.5 ATA na 5.6% na 2.5 ATA. Ya mere, HBOT na-achọ ịkwalite akụkụ a nke ikuku oxygen gbazere, nke ọmana-abawanye ụba oxygen anụ ahụ na mpaghara ischemic. Na nrụgide dị elu, ikuku oxygen na-agbasa ngwa ngwa n'ime anụ ahụ hypoxic, na-erute ogologo mgbasa ozi ogologo ma e jiri ya tụnyere nrụgide ikuku nkịtị.
Ka ọ dị ugbu a, HBOT ahụla ngwa zuru ebe niile maka ọrịa strok ischemic na hemorrhagic. Nnyocha na-egosi na HBOT na-enye mmetụta neuroprotective site na ọtụtụ ihe mgbagwoju anya molecular, biochemical, na hemodynamic, gụnyere:
1. Mmụba ikuku oxygen na-eme ka akụkụ ahụ dịkwuo elu, na-eme ka nnyefe oxygen na ụbụrụ ụbụrụ dịkwuo mma.
2. Nkwụsi ike nke BBB, na-ebelata edema ụbụrụ.
3. nkwalite nke ụbụrụmicrocirculation, na-emeziwanye metabolism nke ụbụrụ na mmepụta ume ka ị na-ejigide homeostasis ion cell.
4. Iwu nke ọbara ụbụrụ nke ụbụrụ iji belata nrụgide intracranial ma belata ọzịza ụbụrụ.
5. Attenuation nke neuroinflammation post-stroke.
6. Mbelata nke apoptosis na necrosisna-eso ọrịa strok.
7. Mbelata nke nrụgide oxidative na mgbochi nke mmerụ ahụ reperfusion, dị oke egwu na ọrịa strok pathophysiology.
8. Nnyocha na-egosi na HBOT nwere ike belata vasospasm na-esote hemorrhage subarachnoid aneurysmal (SAH).
9. Ihe akaebe na-akwadokwa uru nke HBOT n'ịkwalite neurogenesis na angiogenesis.
Mmechi
Usoro ọgwụgwọ hyperbaric oxygen na-enye ụzọ dị mma maka ọgwụgwọ ọrịa strok. Ka anyị na-aga n'ihu na-akọwapụta mgbagwoju anya nke mgbake ọrịa strok, nyocha ndị ọzọ ga-adị mkpa iji mee ka nghọta anyị banyere oge, usoro ọgwụgwọ, na usoro nke HBOT.
Na nchịkọta, ka anyị na-enyocha uru nke ọgwụgwọ hyperbaric oxygen maka ọrịa strok, ọ na-apụta ìhè na ijikọta ọgwụgwọ a nwere ike ime ka anyị gbanwee ụzọ anyị si ejikwa ọrịa strok ischemic, na-enye ndị na-emetụta ọnọdụ a na-agbanwe ndụ.
Ọ bụrụ na ị nwere mmasị ịgagharị ọgwụgwọ hyperbaric oxygen dị ka ihe nwere ike ịgwọ ọrịa mgbake ọrịa strok, anyị na-akpọ gị òkù ka ị gaa na webụsaịtị anyị ka ịmatakwu banyere ụlọ anyị hyperbaric oxygen ụlọ. N'iji ụdị dị iche iche emebere maka ụlọ na ndị ọkachamara, MACY-PAN na-enye ngwọta nke na-ebuga ọgwụgwọ oxygen dị elu, ezubere iche iji kwado ahụike gị na njem mgbake.
Chọpụta ngwaahịa anyị yana otu ha nwere ike isi kwalite ọdịmma gị nawww.hbotmacypan.com.
Oge nzipu: Feb-18-2025