N'ebe a na-ahụ maka ọgwụ ọgbara ọhụrụ, ọgwụ nje egosila na ọ bụ otu n'ime ọganihu ndị kacha pụta ìhè, na-ebelata n'ike n'ike n'ihe omume na ọnụ ọgụgụ ọnwụ ndị metụtara nje nje microbial. Ikike ha nwere ịgbanwe nsonaazụ ụlọ ọgwụ nke nje na-efe efe agbatịwo ogologo ndụ nke ọtụtụ ndị ọrịa. Ọgwụ nje dị oke egwu na usoro ahụike siri ike, gụnyere ịwa ahụ, ntinye ntinye, transplants, na chemotherapy. Otú ọ dị, mpụta nke nje nje na-eguzogide ọgwụ bụ ihe na-akpata nchegbu na-arịwanye elu, na-ebelata ịdị irè nke ọgwụ ndị a ka oge na-aga. Edekọwo ihe atụ nke nguzogide ọgwụ nje n'ofe ụdị ọgwụ nje niile ka mmụgharị microbial na-eme. Nrụgide nhọrọ nke ọgwụ ndị na-egbochi nje na-akpata etinyewo aka na ịrị elu nke ụdị ndị na-eguzogide ọgwụ, na-ebute nnukwu ihe ịma aka na ahụike zuru ụwa ọnụ.
Iji lụso nsogbu dị egwu ọgụ nke mgbochi nje, ọ dị mkpa iji mejuputa atumatu njikwa ọrịa dị irè nke na-ebelata mgbasa nke nje na-eguzogide ọgwụ, yana ibelata ojiji nke ọgwụ nje. Ọzọkwa, enwere mkpa dị mkpa maka ụzọ ọgwụgwọ ọzọ. Hyperbaric Oxygen Therapy (HBOT) apụtala dị ka usoro na-ekwe nkwa na ọnọdụ a, gụnyere iku ume nke 100% oxygen na ọkwa nrụgide ụfọdụ maka oge. N'ịbụ onye e debere dị ka ọgwụgwọ bụ isi ma ọ bụ nkwado maka ọrịa, HBOT nwere ike inye olileanya ọhụrụ n'ịgwọ nnukwu ọrịa nje na-eguzogide ọgwụ nje.
A na-eji usoro ọgwụgwọ a eme ihe dị ka ọgwụgwọ mbụ ma ọ bụ ọgwụgwọ ọzọ maka ọnọdụ dị iche iche, gụnyere mbufụt, nsị carbon monoxide, ọnya na-adịghị ala ala, ọrịa ischemic, na ọrịa. Ngwa ụlọ ọgwụ nke HBOT na ọgwụgwọ ọrịa dị omimi, na-enye ndị ọrịa uru bara uru.
Ngwa Clinical nke Hyperbaric Oxygen Therapy na Ọrịa
Ihe akaebe dị ugbu a na-akwado ngwa HBOT n'ụzọ siri ike, ma dị ka ọgwụgwọ kwụ ọtọ na mgbakwunye, na-ewetara ndị ọrịa butere nnukwu uru. N'oge HBOT, ikuku oxygen nke akwara akwara nwere ike ịrị elu ruo 2000 mmHg, na nsonaazụ elu oxygen-tissue gradient nwere ike ibuli ọkwa oxygen anụ ahụ ruo 500 mmHg. Mmetụta dị otú ahụ bara uru karịsịa n'ịkwalite ọgwụgwọ nke nzaghachi mkpali na mmebi microcirculatory a na-ahụ na gburugburu ebe obibi nke ischemic, yana ijikwa ọrịa nke akụkụ ahụ.
HBOT nwekwara ike imetụta ọnọdụ ndị dabere na sistemu ahụ ji alụso ọrịa ọgụ. Nnyocha na-egosi na HBOT nwere ike igbochi ọrịa autoimmune na nzaghachi mgbochi nke antigen, na-enyere aka ịnọgide na-enwe ntachi obi site n'ibelata mgbasa nke lymphocytes na leukocytes ka ọ na-emezi nzaghachi mgbochi. Ọzọkwa, HBOTna-akwado ọgwụgwọna ọnya anụ ahụ na-adịghị ala ala site na-akpali akpali angiogenesis, usoro dị oke mkpa maka mgbake ka mma. Usoro ọgwụgwọ a na-akwadokwa nhazi nke collagen matrix, akụkụ dị mkpa na ọgwụgwọ ọnya.
A ghaghị inye nlebara anya pụrụ iche maka ọrịa ụfọdụ, karịsịa nke miri emi na nke siri ike ịgwọ ọrịa dị ka necrotizing fasciitis, osteomyelitis, ọrịa anụ ahụ dị nro na-adịghị ala ala, na ọrịa endocarditis na-efe efe. Otu n'ime ngwa ụlọ ọgwụ a na-ahụkarị nke HBOT bụ maka ọrịa anụ ahụ dị nro na osteomyelitis jikọtara ya na ọkwa oxygen dị ala nke na-emekarị site na anaerobic ma ọ bụ nje na-eguzogide ọgwụ.
1. Ọrịa shuga na-arịa ọrịa shuga
Ụkwụ ọrịa shugaọnya bụ ihe mgbagwoju anya n'etiti ndị ọrịa mamịrị, na-emetụta ihe ruru 25% nke ndị a. Ọrịa na-ebilite ugboro ugboro na ọnya ndị a (na-agụta 40%-80% nke ikpe) na-eduga n'ọrịa na-anwụ anwụ. Ọrịa ụkwụ na-arịa ọrịa shuga (DFIs) na-enwekarị ọrịa polymicrobial nwere ụdị nje nje anaerobic dị iche iche amatara. Ihe dị iche iche, gụnyere ntụpọ ọrụ fibroblast, okwu nhazi nke collagen, usoro mgbochi cellular, na ọrụ phagocyte, nwere ike igbochi ọgwụgwọ ọnya na ndị ọrịa na-arịa ọrịa shuga. Ọtụtụ nchọpụta achọpụtala ikuku oxygenation akpụkpọ ahụ na-adịghị mma dị ka ihe ize ndụ siri ike maka igbupụ ihe metụtara DFI.
Dị ka otu n'ime nhọrọ dị ugbu a maka ọgwụgwọ DFI, A kọwawo HBOT na-eme ka ọ̀tụ̀tụ̀ ọgwụgwọ dị mma maka ọnya ụkwụ na-arịa ọrịa shuga na-ebelata nke ukwuu, na-emesịa belata mkpa e bepụ ahụ na usoro ịwa ahụ gbagwojuru anya. Ọ bụghị naanị na ọ na-ebelata mkpa ọ dị maka usoro mkpata akụrụngwa, dị ka ịwa ahụ flap na grafting akpụkpọ, kamakwa ọ na-eweta ọnụ ala dị ala yana mmetụta dị ntakịrị ma e jiri ya tụnyere nhọrọ ịwa ahụ. Ọmụmụ Chen et al. gosipụtara na ihe karịrị oge 10 nke HBOT mere ka mmụba 78.3% dị na ọnụ ọgụgụ ọgwụgwọ ọnya na ndị ọrịa na-arịa ọrịa shuga.
2. Necrotizing Soft Tissue Infection
Ọrịa anụ ahụ dị nro nke necrotizing (NSTIs) na-abụkarị polymicrobial, nke na-esite na nchikota nke nje bacteria na aerobic na anaerobic na-ejikọta ya na mmepụta gas. Ọ bụ ezie na NSTI dị ụkọ, ha na-ebute ọnụ ọgụgụ ọnwụ dị elu n'ihi ọganihu ha na-aga ngwa ngwa. Nchọpụta na ọgwụgwọ kwesịrị ekwesị n'oge bụ isi ihe iji nweta nsonaazụ dị mma, a kwadokwara HBOT ka ọ bụrụ usoro mgbakwunye maka ijikwa NSTIs. Ọ bụ ezie na a ka nwere esemokwu gbasara ojiji HBOT na NSTI n'ihi enweghị ọmụmụ ihe a na-achịkwa nke ọma.ihe akaebe na-egosi na enwere ike jikọta ya na ọnụọgụ ndụ ka mma yana nchekwa akụkụ ahụ na ndị ọrịa NSTI.. Nnyocha e mere nlegharị anya gosiri mbelata dị ukwuu na ọnụọgụ ọnwụ n'etiti ndị ọrịa NSTI na-anata HBOT.
1.3 Ọrịa saịtị ịwa ahụ
Enwere ike kewaa SSIs dabere na saịtị ahụ nke ọrịa ahụ ma nwee ike ibilite site na nje dị iche iche, gụnyere ma nje aerobic na anaerobic. N'agbanyeghị ọganihu a na-enwe na usoro nchịkwa ọrịa, dị ka usoro ịgba ọgwụ mgbochi ọrịa, iji ọgwụ nje prophylactic eme ihe, na nkwalite na usoro ịwa ahụ, SSI na-anọgide na-enwe mgbagwoju anya.
Otu nyocha dị ịrịba ama enyochala ịdị irè nke HBOT na igbochi SSI miri emi na ịwa ahụ scoliosis neuromuscular. HBOT tupu ịwa ahụ nwere ike ibelata mkpamkpa nke SSI ma kwado ọgwụgwọ ọnya. Usoro ọgwụgwọ a na-adịghị emerụ ahụ na-emepụta gburugburu ebe ikuku oxygen dị na anụ ahụ ọnya na-ebuli elu, bụ nke e jikọtara ya na igbu egbu oxidative megide ọrịa nje. Na mgbakwunye, ọ na-eleba anya n'ọbara ala na ọkwa oxygen na-enye aka na mmepe nke SSI. E wezụga usoro nchịkwa ọrịa ndị ọzọ, HBOT ka akwadoro karịsịa maka ịwa ahụ emerụrụ emerụ dị ka usoro agba.
1.4 Ọkụ
Ọkụ bụ mmerụ ahụ nke oke okpomọkụ, ọkụ eletrik, kemịkalụ, ma ọ bụ radieshon na-ebute ma nwee ike ibute oke ọrịa na ọnụ ọgụgụ ọnwụ. HBOT bara uru n'ịgwọ ọkụ site n'ịbawanye ọkwa oxygen na anụ ahụ mebiri emebi. Ọ bụ ezie na anụmanụ na ụlọ ọgwụ ọmụmụ na-eweta agwakọta results banyereịdị irè nke HBOT na ọgwụgwọ ọkụ, Nnyocha nke metụtara ndị ọrịa 125 na-ere ọkụ na-egosi na HBOT egosighị mmetụta dị ịrịba ama na ọnụ ọgụgụ ndị na-anwụ anwụ ma ọ bụ ọnụ ọgụgụ nke ịwa ahụ a na-eme ma belata oge ọgwụgwọ oge (ụbọchị 19.7 ma e jiri ya tụnyere 43.8 ụbọchị). Ijikọ HBOT na njikwa ọkụ zuru oke nwere ike ịchịkwa sepsis nke ọma na ndị ọrịa na-agba ọkụ, na-eduga n'oge ọgwụgwọ dị mkpụmkpụ yana belata ihe achọrọ mmiri. Otú ọ dị, a ga-achọrọ nyocha ọzọ dị ukwuu iji kwado ọrụ HBOT na njikwa nke nnukwu ọkụ.
1.5 osteomyelitis
Osteomyelitis bụ ọrịa na-efe efe nke ọkpụkpụ ma ọ bụ ụmị ọkpụkpụ nke nje bacteria na-ebutekarị. Ịgwọ ọrịa osteomyelitis nwere ike bụrụ ihe ịma aka n'ihi ọbara na-adịghị mma nke ọkpụkpụ na ntinye nke ọgwụ nje n'ime ụmị. Ihe e ji mara osteomyelitis na-adịghị ala ala bụ ọrịa nje na-adịgide adịgide, mbufụt dị nro, na ọkpụkpụ necrotic ọkpụkpụ. Refractory osteomyelitis na-ezo aka na ọrịa ọkpụkpụ na-adịghị ala ala nke na-aga n'ihu ma ọ bụ na-emegharị n'agbanyeghị ọgwụgwọ kwesịrị ekwesị.
E gosiputara HBOT na-eme ka ọkwa oxygen dịkwuo elu n'ime anụ ahụ nwere ọrịa. Ọtụtụ usoro ikpe na ọmụmụ ihe na-egosi na HBOT na-eme ka ọ pụta ìhè maka ndị ọrịa osteomyelitis. Ọ dị ka ọ na-arụ ọrụ site na usoro dị iche iche, gụnyere ịkwalite ọrụ metabolic, na-egbochi nje bacteria, ịkwalite mmetụta nje, na-ebelata mbufụt, na ịkwalite ọgwụgwọ.usoro. Post-HBOT, 60% ruo 85% nke ndị ọrịa na-adịghị ala ala, osteomyelitis refractory na-egosi ihe ịrịba ama nke nkwụsị ọrịa.
1.6 Ọrịa fungal
N'ụwa niile, ihe karịrị nde mmadụ atọ na-arịa ọrịa fungal na-adịghị ala ala ma ọ bụ nke na-emebi emebi, na-ebute ọnwụ karịrị 600,000 kwa afọ. A na-emebikarị nsonaazụ ọgwụgwọ maka ọrịa fungal n'ihi ihe ndị dị ka ọnọdụ mgbochi ọrịa gbanwere, ọrịa ndị na-akpata, na njirimara nje nje pathogen. HBOT na-aghọ nhọrọ ọgwụgwọ mara mma na ọrịa fungal siri ike n'ihi nchekwa ya na ọdịdị na-adịghị emerụ ahụ. Nnyocha na-egosi na HBOT nwere ike ịdị irè megide nje fungal dị ka Aspergillus na Mycobacterium ụkwara nta.
HBOT na-akwalite mmetụta antifungal site na igbochi nhazi biofilm nke Aspergillus, yana nrịbawanye arụmọrụ achọpụtara na ụdị enweghị mkpụrụ ndụ ihe nketa superoxide dismutase (SOD). Ọnọdụ hypoxic n'oge ọrịa fungal na-ebute ihe ịma aka nye nnyefe ọgwụ antifungal, na-eme ka ọkwa oxygen na-abawanye site na HBOT nwere ike ịba uru, ọ bụ ezie na nyocha ọzọ dị mkpa.
Njirimara Antimicrobial nke HBOT
Gburugburu hyperoxic nke HBOT mepụtara na-amalite mgbanwe physiological na biochemical nke na-akpali ihe ndị na-egbu nje, na-eme ka ọ bụrụ ọgwụgwọ mgbakwunye dị irè maka ọrịa. HBOT na-egosiputa mmetụta dị ịrịba ama megide nje bacteria aerobic na nje bacteria anaerobic kachasị site na usoro dị ka ọrụ nje bacteria kpọmkwem, nkwalite nke nzaghachi mgbochi, na mmetụta synergistic na ndị ọrụ antimicrobial kpọmkwem.
2.1 Mmetụta mgbochi nje kpọmkwem nke HBOT
Mmetụta nje bacteria HBOT na-adabere n'ụzọ dị ukwuu n'ọgbọ nke ụdị oxygen na-emeghachi omume (ROS), nke gụnyere anions superoxide, hydrogen peroxide, hydroxyl radicals, na hydroxyl ion-ha niile na-ebilite n'oge metabolism cell.
Mmekọrịta dị n'etiti O₂ na cellular components dị mkpa n'ịghọta ka ROS si etolite n'ime sel. N'okpuru ọnọdụ ụfọdụ a na-akpọ nrụgide oxidative, nguzozi n'etiti nhazi ROS na mmebi ya na-emebi, na-eduga n'ọkwa ROS dị elu na sel. A na-eme ka mmepụta nke superoxide (O₂⁻) site na superoxide dismutase, nke emesịa gbanwee O₂⁻ ka ọ bụrụ hydrogen peroxide (H₂O₂). Ntughari a na-emewanyewanye site na mmeghachi omume Fenton, nke na-eme ka Fe²⁺ mepụta hydroxyl radicals (·OH) na Fe³⁺, si otú a na-ebute usoro redox na-adịghị mma nke nhazi ROS na mmebi cellular.
Mmetụta na-egbu egbu nke ROS lekwasịrị anya akụkụ cellular dị mkpa dị ka DNA, RNA, protein, na lipids. N'ụzọ doro anya, DNA bụ isi ebumnuche nke cytotoxicity mgbasa ozi H₂O₂, ebe ọ na-akpaghasị ihe owuwu deoxyribose ma mebie ihe ndị mejupụtara ya. Mmebi anụ ahụ nke ROS kpatara na-agbatị n'usoro helix nke DNA, nke nwere ike ịpụta site na peroxidation lipid nke ROS kpalitere. Nke a na-akọwapụta nsonaazụ ọjọọ nke ọkwa ROS dị elu n'ime sistemu ndu.
Antimicrobial Action nke ROS
ROS na-ekere òkè dị mkpa n'ịgbochi uto microbial, dị ka egosipụtara site na HBOT na-ebute ROS ọgbọ. Mmetụta nsi nke ROS na-elekwasị anya kpọmkwem ihe mejupụtara sel dị ka DNA, protein, na lipids. Ọnụnọ dị elu nke ụdị oxygen na-arụ ọrụ nwere ike imebi lipids ozugbo, na-eduga na peroxidation lipid. Usoro a na-emebi iguzosi ike n'ezi ihe nke membranes cell na, ya mere, ọrụ nke ndị na-anabata akpụkpọ ahụ na protein.
Ọzọkwa, ndị na-edozi ahụ, nke bụkwa ihe mgbaru ọsọ molekụla dị ịrịba ama nke ROS, na-enweta mgbanwe oxidative kpọmkwem na amino acid dị iche iche dị ka cysteine, methionine, tyrosine, phenylalanine, na tryptophan. Dịka ọmụmaatụ, egosiri na HBOT na-ebute mgbanwe oxidative na ọtụtụ protein na E. coli, gụnyere elongation factor G na DnaK, si otú ahụ na-emetụta ọrụ cellular ha.
Ịkwalite mgbochi site na HBOT
Njirimara mgbochi mkpali nke HBOTedepụtala akwụkwọ, na-egosi na ọ dị oke mkpa maka ibelata mmebi anụ ahụ yana igbochi ọganihu ọrịa. HBOT na-emetụta okwu nke cytokines na ndị ọzọ na-achịkwa mkpasu iwe, na-emetụta nzaghachi mgbochi. Usoro nnwale dị iche iche hụrụ mgbanwe dị iche iche na okwu mkpụrụ ndụ ihe nketa na ọgbọ protein post-HBOT, nke na-emezigharị ma ọ bụ mebie ihe uto na cytokines.
N'oge usoro HBOT, ụbara ọkwa O₂ na-akpalite nzaghachi dị iche iche nke cell, dị ka igbochi ntọhapụ nke ndị mgbasa ozi pro-inflammatory na ịkwalite lymphocyte na neutrophil apoptosis. N'otu oge, omume ndị a na-eme ka usoro ahụ ji alụso ọrịa ọgụ sikwuo ike, si otú a na-eme ka a gwọọ ọrịa.
Ọzọkwa, ọmụmụ na-egosi na mmụba O₂ n'oge HBOT nwere ike ibelata okwu nke cytokines pro-inflammatory, gụnyere interferon-gamma (IFN-γ), interleukin-1 (IL-1), na interleukin-6 (IL-6). Mgbanwe ndị a gụnyekwara iwetulata oke CD4: sel CD8 T yana mezie ndị nnabata soluble ndị ọzọ, n'ikpeazụ na-ebuli ọkwa interleukin-10 (IL-10), nke dị oke mkpa maka igbochi mbufụt na ịkwalite ọgwụgwọ.
Ihe omume antimicrobial nke HBOT jikọtara ya na usoro ndu mgbagwoju anya. A kọwo ma superoxide na nrụgide dị elu ka ha na-akwalite ọrụ nje bacteria na-akpata HBOT na neutrophil apoptosis. Na-eso HBOT, elu pụtara ìhè na ọkwa oxygen na-eme ka ike bactericidal nke neutrophils dịkwuo elu, akụkụ dị mkpa nke nzaghachi mgbochi ahụ. Ọzọkwa, HBOT na-egbochi adhesion neutrophil, nke na-emekọrịta ihe site na mmekọrịta nke β-integrin na neutrophils na intercellular adhesion molecules (ICAM) na sel endothelial. HBOT na-egbochi ọrụ nke neutrophil β-2 integrin (Mac-1, CD11b / CD18) site na usoro nitric oxide (NO), na-enye aka na ntinye nke neutrophils na saịtị nke ọrịa.
Nhazi nhazi nke cytoskeleton dị mkpa maka neutrophils iji phagocytize pathogens nke ọma. E gosipụtara S-nitrosylation nke actin iji kpalie actin polymerization, nwere ike ịkwado ọrụ phagocytic nke neutrophils mgbe ọgwụgwọ HBOT gasịrị. Ọzọkwa, HBOT na-akwalite apoptosis n'ahịrị sel T mmadụ site na ụzọ mitochondrial, na-akọpụta ọnwụ lymphocyte ngwa ngwa post-HBOT. Mgbochi caspase-9-na-enweghị mmetụta caspase-8-egosila mmetụta immunomodulatory nke HBOT.
Mmetụta Synergistic nke HBOT na ndị ọrụ mgbochi
Na ngwa ụlọ ọgwụ, a na-ejikarị HBOT na ọgwụ nje iji luso ọrịa ọgụ nke ọma. Ọnọdụ hyperoxic enwetara n'oge HBOT nwere ike imetụta ịdị mma nke ụfọdụ ọgwụ nje. Nnyocha na-egosi na ọgwụ nje nje ndị dị ka β-lactams, fluoroquinolones, na aminoglycosides, ọ bụghị nanị na-eme ihe site na usoro dị iche iche kamakwa na-adabere n'akụkụ ụfọdụ na metabolism aerobic nke nje bacteria. Ya mere, ọnụnọ oxygen na njirimara metabolic nke pathogens bụ ihe dị mkpa mgbe ị na-enyocha mmetụta ọgwụgwọ nke ọgwụ nje.
Ihe akaebe pụtara ìhè egosila na ikuku oxygen dị ala nwere ike ime ka Pseudomonas aeruginosa na-eguzogide piperacillin / tazobactam nakwa na ikuku oxygen dị ala na-enyekwa aka na mmụba nke Enterobacter cloacae na azithromycin. N'aka nke ọzọ, ụfọdụ ọnọdụ hypoxic nwere ike ịkwalite mmetụta nje na nje tetracycline. HBOT na-eje ozi dị ka usoro ọgwụgwọ na-edozi ahụ nke nwere ike ime site n'ịkwalite metabolism aerobic na reoxygenating anụ ahụ butere ọrịa hypoxic, na-emesị na-abawanye mmetụta nke nje nje na ọgwụ nje.
N'ime ọmụmụ ihe ọmụmụ, nchikota HBOT-a na-enye ugboro abụọ kwa ụbọchị maka awa 8 na 280 kPa-n'akụkụ tobramycin (20 mg / kg / ụbọchị) na-ebelata ibu nje bacteria na Staphylococcus aureus endocarditis na-efe efe. Nke a na-egosipụta ike HBOT dị ka ọgwụgwọ inyeaka. Nnyocha ndị ọzọ egosila na n'okpuru 37 Celsius C na 3 ATA mgbali maka awa 5, HBOT kwalitere mmetụta nke imipenem megide Pseudomonas aeruginosa na-ebute macrophage. Na mgbakwunye, a chọpụtara na usoro HBOT jikọtara ọnụ na cephazolin na-adị irè karị n'ịgwọ Staphylococcus aureus osteomyelitis n'ụdị anụmanụ ma e jiri ya tụnyere cephazolin naanị.
HBOT na-abawanye nke ukwuu ọrụ nje nke ciprofloxacin megide Pseudomonas aeruginosa biofilms, ọkachasị mgbe nkeji 90 gachara. Nkwalite a bụ n'ihi nguzobe nke ụdị oxygen na-emeghachi omume (ROS) ma na-egosiputa mmetụta dị elu na mutant peroxidase-adịghị arụ ọrụ.
N'ụdị pleuritis nke methicillin na-eguzogide Staphylococcus aureus (MRSA) kpatara, mmekọ ọnụ nke vancomycin, teicoplanin na linezolid na HBOT gosipụtara mmetụta dị ukwuu megide MRSA. Metronidazole, ọgwụ nje nje a na-ejikarị eme ihe n'ịgwọ ọrịa anaerobic na polymicrobial siri ike dị ka ọrịa ụkwụ na-arịa ọrịa shuga (DFIs) na ebe ịwa ahụ (SSI), egosipụtala irè antimicrobial dị elu n'okpuru ọnọdụ anaerobic. Ọmụmụ ihe n'ọdịnihu ka enyere ikike inyocha mmetụta nje antibacterial synergistic nke HBOT jikọtara ya na metronidazole na ma na vivo na ntọala in vitro.
Mmetụta mgbochi nje nke HBOT na nje bacteria na-eguzogide
Site na mmalite na mgbasa nke ụdị na-eguzogide ọgwụ, ọgwụ mgbochi ọdịnala na-efunahụ ike ha ka oge na-aga. Ọzọkwa, HBOT nwere ike bụrụ ihe dị mkpa n'ịgwọ na igbochi ọrịa nke nje na-eguzogide ọgwụ na-akpata, na-eje ozi dị ka atụmatụ dị oke egwu mgbe ọgwụgwọ ọgwụ nje na-ada. Ọtụtụ nchọpụta akọpụtala mmetụta nje bacteria HBOT dị na nje bacteria na-eguzogide ọgwụ. Dịka ọmụmaatụ, nnọkọ HBOT nkeji 90 na 2 ATM belatara uto nke MRSA. Na mgbakwunye, n'ụdị nha, HBOT akwalitela mmetụta antibacterial nke ọgwụ nje dị iche iche megide ọrịa MRSA. Akụkọ ekwenyela na HBOT dị irè n'ịgwọ ọrịa osteomyelitis nke OXA-48 na-emepụta Klebsiella pneumoniae kpatara na-enweghị mkpa ọ bụla ọgwụ nje na-akwado ya.
Na nchịkọta, ọgwụgwọ oxygen hyperbaric na-anọchite anya ụzọ dị iche iche maka ịchịkwa ọrịa, na-eme ka mmeghachi omume na-alụso ọrịa ọgụ dịkwuo elu ma na-eme ka ọ dị irè nke ndị na-ahụ maka nje ndị dị ugbu a. Site na nyocha na mmepe zuru oke, ọ na-enwe ike ibelata mmetụta nke nguzogide ọgwụ nje, na-enye olileanya n'ọgụ na-aga n'ihu megide nje nje.
Oge nzipu: Feb-28-2025