Ụzọ na-ekwe nkwa maka Ọrịa Neurodegenerative: Hyperbaric Oxygen Therapy

Ịghọta Hyperbaric Oxygen Therapy (HBOT)

HBOT na-agụnye ịba ụba n'elu 1 zuru oke ikuku (ATA) - nrụgide na oke osimiri - maka oge 90-120 nkeji, na-achọkarị ọtụtụ nnọkọ dabere na ọnọdụ a na-agwọ. Nrụgide ikuku na-eme ka ọ dịkwuo mma nnyefe oxygen na sel, nke n'aka nke ya na-akpalite mmụba nke cell cell ma na-eme ka usoro ọgwụgwọ na-edozi site na ihe ụfọdụ na-eto eto.

Na mbụ, ngwa nke HBOT tọrọ ntọala na iwu Boyle-Marriott, nke na-eme ka mbelata na-adabere na nrụgide nke ikuku gas, n'akụkụ uru nke ọkwa oxygen dị elu na anụ ahụ. Enwere ụdị ọrịa dị iche iche a maara na-erite uru site na ọnọdụ hyperoxic nke HBOT na-emepụta, gụnyere anụ ahụ necrotic, mmerụ ahụ radieshon, trauma, ọkụ, ọrịa akụkụ, na gangrene gas, n'etiti ndị ọzọ depụtara site na Undersea na Hyperbaric Medical Society. N'ụzọ doro anya, HBOT egosiwokwa ịdị irè dị ka ọgwụgwọ mgbakwunye na ụdị ọrịa mkpali dị iche iche ma ọ bụ ọrịa na-efe efe, dị ka colitis na sepsis. Nyere usoro mgbochi mkpali na oxidative, HBOT na-enye ikike dị ukwuu dị ka ụzọ ọgwụgwọ maka ọrịa neurodegenerative.

 

Ọmụmụ ihe ọmụmụ ihe gbasara ọgwụgwọ hyperbaric oxygen na ọrịa Neurodegenerative: Nhụta sitere na 3 × Tg Mouse Model

Otu n'ime ọmụmụ ihe ama amalekwasịrị anya na ụdị òké 3 × Tg nke ọrịa Alzheimer (AD), bụ nke gosipụtara ike ọgwụgwọ nke HBOT n'ịkwalite ụkọ ọgụgụ isi. Nnyocha ahụ metụtara ụmụ oke 3 × Tg nwoke dị ọnwa 17 ma e jiri ya tụnyere ụmụ oke C57BL/6 dị ọnwa 14 na-eje ozi dị ka njikwa. Ọmụmụ ihe ahụ gosipụtara na HBOT ọ bụghị nanị na ọ na-eme ka ọrụ ọgụgụ isi dịkwuo mma kamakwa ọ na-ebelata mbufụt, ibu plaque, na Tau phosphorylation-usoro dị oke egwu metụtara AD pathology.

Ekwuru na mmetụta nchebe nke HBOT sitere na mbelata nke neuroinflammation. E gosipụtara nke a site na mbelata mmụba nke microglial proliferation, astrogliosis, na nzuzo nke cytokines pro-inflammatory. Nchọpụta ndị a na-emesi ike ọrụ abụọ nke HBOT n'ịkwalite arụmọrụ ọgụgụ isi ma na-ebelata usoro neuroinflammatory metụtara ọrịa Alzheimer.

Ihe atụ ọzọ nke preclinical jiri 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) ụmụ oke iji nyochaa usoro nchebe nke HBOT na ọrụ neuronal na ike moto. Nsonaazụ gosiri na HBOT nyere aka n'ịrụ ọrụ moto na ike ijide ụmụ oke ndị a, na-ejikọta na mmụba nke mitochondrial biogenesis signing, kpọmkwem site na ịgbalite SIRT-1, PGC-1α, na TFAM. Nke a na-akọwapụta ọrụ dị mkpa nke ọrụ mitochondrial na mmetụta neuroprotective nke HBOT.

 

Usoro nke HBOT na Ọrịa Neurodegenerative

Ụkpụrụ dị n'okpuru nke iji HBOT maka NDD bụ mmekọrịta dị n'etiti mbelata ikuku oxygen na ike nke mgbanwe neurodegenerative. Hypoxia-inducible factor-1 (HIF-1) na-arụ ọrụ dị n'etiti dị ka ihe ntụgharị ederede nke na-eme ka mmegharị cellular na esemokwu ikuku oxygen dị ala ma tinye ya na NDD dị iche iche gụnyere AD, PD, Huntington's Disease, na ALS, na-akara ya dị ka ebumnuche ọgwụ dị mkpa.

N'ihi afọ bụ nnukwu ihe ize ndụ maka ọtụtụ ọrịa neurodegenerative, nyocha mmetụta HBOT na neurobiology ịka nká dị mkpa. Nnyocha e mere egosiwo na HBOT nwere ike imeziwanye ụkọ ọgụgụ isi metụtara afọ na isiokwu ndị agadi nwere ahụike.Na mgbakwunye, ndị ọrịa agadi nwere nnukwu nsogbu ebe nchekwa gosipụtara mmụba nke ọgụgụ isi yana mmụba ọbara ụbụrụ na-esochi ikpughe HBOT.

 

1. Mmetụta nke HBOT na mbufụt na nrụgide Oxidative

HBOT egosila ikike ibelata neuroinflammation na ndị ọrịa nwere nnukwu ọrụ ụbụrụ. Ọ nwere ikike iweda cytokines pro-inflammatory (dị ka IL-1β, IL-12, TNFα, na IFNγ) ebe ọ na-akwalite cytokines mgbochi mkpali (dị ka IL-10). Ụfọdụ ndị nchọpụta na-atụ aro na ụdị ikuku oxygen na-emeghachi omume (ROS) nke HBOT na-emepụta na-edozi ọtụtụ mmetụta bara uru nke ọgwụgwọ ahụ. N'ihi nke a, ewezuga ihe omume mbelata afụ na-adabere na nrụgide ya na ịnweta ikuku oxygen saturation nke anụ ahụ dị elu, nsonaazụ dị mma jikọtara na HBOT na-adabere n'otu akụkụ na ọrụ physiological nke ROS emepụtara.

2. Mmetụta HBOT na Apoptosis na Neuroprotection

Nnyocha egosiwo na HBOT nwere ike ibelata phosphorylation hippocampal nke p38 mitogen-activated protein kinase (MAPK), emesia na-emeziwanye cognition na ibelata mmebi hippocampal. Achọpụtara ma HBOT kwụ ọtọ na njikọta na Ginkgo biloba wepụ na-ebelata ngosipụta nke Bax na ọrụ caspase-9/3, na-ebute mbelata ọnụego apoptosis na ụdị òké nke aβ25-35 kpatara. Ọzọkwa, nnyocha ọzọ gosiri na HBOT preconditioning butere ndidi megide cerebral ischemia, na usoro metụtara ụba SIRT1 okwu, n'akụkụ augmented B-cell lymphoma 2 (Bcl-2) etoju na mbelata arụ ọrụ caspase-3, na-emesi HBOT si neuroprotective na mgbochi apoptotic Njirimara.

3. Mmetụta nke HBOT na Circulation naNeurogenesis

Ikpughe isiokwu na HBOT ejikọtara ya na ọtụtụ mmetụta na sistemu vaskụla cranial, gụnyere ịkwalite ikike mgbochi ụbụrụ ọbara-ụbụrụ, ịkwalite angiogenesis, na ibelata edema. Na mgbakwunye na inye ụbara oxygen na anụ ahụ, HBOTna-akwalite nhazi nke vascularsite n'ịgbalite ihe odide ederede dị ka vaskụla endothelial growth factor na site n'ịkwalite mmụba nke mkpụrụ ndụ stem neural.

4. Mmetụta Epigenetic nke HBOT

Nnyocha egosiwo na mkpughe nke mkpụrụ ndụ endothelial microvascular nke mmadụ (HMEC-1) na hyperbaric oxygen na-achịkwa nke ọma mkpụrụ ndụ ihe nketa 8,101, gụnyere ma okwu akwadoro na nke na-agbada, na-egosipụta mmụba nke mkpụrụ ndụ ihe nketa jikọtara na ụzọ nzaghachi antioxidant.